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Biomolecular Condensates and the Chemistry of Life
We study how biomolecular condensates concentrate, organise and activate chemistry. Working with enzymes, nucleic acids, free nucleotides and cofactors, we ask how these compartments regulate catalysis today and how they may have supported the first reactions at the origin of life.
Department of Medicine and Surgery - University of Perugia - Italy
Enzymes and biomolecular condensates
Four connected lines of work, from the chemistry of the first cells to enzymes that fail in human disease.
Prebiotic microreactors
Nucleotide and RNA droplets as models for early chemistry
Enzyme engineering
Redesigning enzymes for biomedical use
Human enzymes & misfolding
Discovery of new human enzymes and study of disease-linked enzymes that fail to fold correctly
Regulation of monoamine synthesis
Uncovering how monoamine-producing enzymes are regulated and shaped by evolution
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